Insight into High-quality Aerodynamic Design Spaces through Multi-objective Optimization

An approach to support the computational aerodynamic design process is presented and demonstrated through the application of a novel multi-objective variant of the Tabu Search optimization algorithm for continuous problems to the aerodynamic design optimization of turbomachinery blades. The aim is to improve the performance of a specific stage and ultimately of the whole engine. The integrated system developed for this purpose is described. This combines the optimizer with an existing geometry parameterization scheme and a well- established CFD package. The system’s performance is illustrated through case studies – one two-dimensional, one three-dimensional – in which flow characteristics important to the overall performance of turbomachinery blades are optimized. By showing the designer the trade-off surfaces between the competing objectives, this approach provides considerable insight into the design space under consideration and presents the designer with a range of different Pareto-optimal designs for further consideration. Special emphasis is given to the dimensionality in objective function space of the optimization problem, which seeks designs that perform well for a range of flow performance metrics. The resulting compressor blades achieve their high performance by exploiting complicated physical mechanisms successfully identified through the design process. The system can readily be run on parallel computers, substantially reducing wall-clock run times – a significant benefit when tackling computationally demanding design problems. Overall optimal performance is offered by compromise designs on the Pareto trade-off surface revealed through a true multi-objective design optimization test case. Bearing in mind the continuing rapid advances in computing power and the benefits discussed, this approach brings the adoption of such techniques in real-world engineering design practice a ste

Physical Activity and Modernization Among Bolivian Amerindians

Background: Physical inactivity is a growing public health problem, and the fourth leading risk factor for global mortality. Conversely, indigenous populations living traditional lifestyles reportedly engage in vigorous daily activity that is protective against non-communicable diseases. Here we analyze physical activity patterns among the Tsimane, forager-horticulturalists of Amazonian Bolivia with minimal heart disease and diabetes. We assess age patterns of adult activity among men and women, test whether modernization affects activity levels, and examine whether nascent obesity is associated with reduced activity. Methods and Findings: A factorial method based on a large sample of behavioral observations was employed to estimate effects of age, sex, body mass index, and modernization variables on physical activity ratio (PAR), the ratio of total energy expenditure to basal metabolic rate. Accelerometry combined with heart rate monitoring was compared to the factorial method and used for nighttime sampling. Tsimane men and women display 24 hr physical activity level (PAL) of 2.02–2.15 and 1.73–1.85, respectively. Little time was spent ‘‘sedentary’’, whereas most activity was light to moderate, rather than vigorous. Activity peaks by the late twenties in men, and declines thereafter, but remains constant among women after the early teens. Neither BMI, fat free mass or body fat percentage are associated with PAR. There was no negative effect of modernization on physical activity. Conclusions: Tsimane display relatively high PALs typical of other subsistence populations, but of moderate intensity, and not outside the range of developed populations. Despite rapidly increasing socioeconomic change, there is little evidence that total activity has yet been affected. Overweight and obesity are more prevalent among women than men, and Spanish fluency is associated with greater obesity in women. The lack of cardiovascular disease among Tsimane is unlikely caused by activity alone; further study of diet, food intake and infectious disease is needed

Parental Hormones are Associated With Crop Loss and Family Sickness Following Catastrophic Flooding in Lowland Bolivia

The physiology of fatherhood is a growing field of study, and variability in hormonal mediators of reproductive effort (e.g. testosterone, cortisol) can predict variability in paternal investment. Studies often find that lower testosterone levels are associated with increased paternal investment, though most studies are conducted under relatively stable ecological conditions. In this paper, we examine parental physiological correlates of crop loss and family health problems among Tsimane forager-horticulturalists following a catastrophic flood in lowland Bolivia. Immediately after a devastating 2014 flood that impacted \u3e75% of Tsimane communities, we conducted structured interviews examining crop losses and morbidity, and collected saliva specimens from 421 parents (n= 292 households) to analyze cortisol and testosterone. Over 98% of interviewees reported horticultural losses, with the average family losing 88% of their crops, while 80% of families reported flood-induced injuries or illnesses. Controlling for age, body mass index, and time of specimen collection, men’s testosterone was negatively associated with both absolute cropland losses (Std. β= −0.16, p=0.037), and percent of cropland lost (Std. β= −0.16, p=0.040). Female testosterone was not associated with crop losses. Using the same control variables, both male and female cortisol was negatively associated with a composite measure of child health burden (fathers: Std. β= −0.34, p\u3c0.001; mothers: Std. β= −0.23, p=0.037). These results are discussed in the cultural context of a strong sexual division of labor among Tsimane; we highlight the physiological and psychosocial costs of experiencing a natural disaster, especially for paternal caregivers in a nutritionally and pathogenically stressed subsistence population where cultigens provide the majority of calories in the diet

Rapidly Declining Body Temperature in a Tropical Human Population

Normal human body temperature (BT) has long been considered to be 37.0°C. Yet, BTs have declined over the past two centuries in the United States, coinciding with reductions in infection and increasing life expectancy. The generality of and reasons behind this phenomenon have not yet been well studied. Here, we show that Bolivian forager-farmers (n = 17,958 observations of 5481 adults age 15+ years) inhabiting a pathogen-rich environment exhibited higher BT when first examined in the early 21st century (~37.0°C). BT subsequently declined by ~0.05°C/year over 16 years of socioeconomic and epidemiological change to ~36.5°C by 2018. As predicted, infections and other lifestyle factors explain variation in BT, but these factors do not account for the temporal declines. Changes in physical activity, body composition, antibiotic usage, and thermal environment are potential causes of the temporal decline

A Latent Factor Analysis of Working Memory Measures Using Large-Scale Data

Working memory (WM) is a key cognitive system that is strongly related to other cognitive domains and relevant for everyday life. However, the structure of WM is yet to be determined. A number of WM models have been put forth especially by factor analytical studies. In broad terms, these models vary by their emphasis on WM contents (e.g., visuospatial, verbal) vs. WM processes (e.g., maintenance, updating) as critical, dissociable elements. Here we conducted confirmatory and exploratory factor analyses on a broad set of WM tasks, half of them numerical-verbal and half of them visuospatial, representing four commonly used task paradigms: simple span, complex span, running memory, and n-back. The tasks were selected to allow the detection of both content-based (visuospatial, numerical-verbal) and process-based (maintenance, updating) divisions. The data were collected online which allowed the recruitment of a large and demographically diverse sample of adults (n = 711). Both factor analytical methods pointed to a clear division according to task content for all paradigms except n-back, while there was no indication for a process-based division. Besides the content-based division, confirmatory factor analyses supported a model that also included a general WM factor. The n-back tasks had the highest loadings on the general factor, suggesting that this factor reflected high-level cognitive resources such as executive functioning and fluid intelligence that are engaged with all WM tasks, and possibly even more so with the n-back. Together with earlier findings that indicate high variability of process-based WM divisions, we conclude that the most robust division of WM is along its contents (visuospatial vs. numerical-verbal), rather than along its hypothetical subprocesses

Differences in navigation performance and postpartal striatal volume associated with pregnancy in humans.

Pregnancy is accompanied by prolonged exposure to high estrogen levels. Animal studies have shown that estrogen influences navigation strategies and, hence, affects navigation performance. High estrogen levels are related to increased use of hippocampal-based allocentric strategies and decreased use of striatal-based egocentric strategies. In humans, associations between hormonal shifts and navigation strategies are less well studied. This study compared 30 peripartal women (mean age 28 years) to an age-matched control group on allocentric versus egocentric navigation performance (measured in the last month of pregnancy) and gray matter volume (measured within two months after delivery). None of the women had a previous pregnancy before study participation. Relative to controls, pregnant women performed less well in the egocentric condition of the navigation task, but not the allocentric condition. A whole-brain group comparison revealed smaller left striatal volume (putamen) in the peripartal women. Across the two groups, left striatal volume was associated with superior egocentric over allocentric performance. Limited by the cross-sectional study design, the findings are a first indication that human pregnancy might be accompanied by structural brain changes in navigation-related neural systems and concomitant changes in navigation strategy

Multi-objective Optimisation of Turbomachinery Blades Using Tabu Search

This paper describes the application of a new multi-objective integrated turbomachinery blade design optimisation system. The system combines an existing geometry parameterisation scheme, a well-established CFD package and a novel multi-objective variant of the Tabu Search optimisation algorithm. Two case studies, in which the flow characteristics most important to the overall performance of turbomachinery blades are optimised, are investigated. Results are presented and compared with a previous (single-objective) investigation of the problem

Geochemical fingerprinting of key lithologies and depositional processes across the upper boundary of the Opalinus Clay (Aalenian, Middle Jurassic, northern Switzerland)

The Opalinus Clay is an argillaceous to silty mudstone formation, notable in Switzerland as the selected host rock for deep geological disposal of radioactive waste. Its upper bounding unit (Passwang Formation and eastern equivalents) is composed of successions of mudstone, sandy bioclastic marl and limestone separated by ooidal ironstone beds. The lithostratigraphic transition is diachronous across northern Switzerland and shows high vertical and lateral lithological variability. To constrain this variability into predictive models, and to identify horizons with properties that could potentially influence radionuclide mobility, the sedimentological and diagenetic processes involved in the genesis of this transition have to be investigated. The present study aims at testing the applicability of X‐ray fluorescence chemostratigraphy to characterise the mixed carbonate–siliciclastic units and understand the complex genesis of the lithostratigraphic transition from the Opalinus Clay towards its upper bounding unit. Sediment drill cores from four locations across northern Switzerland (Mont Terri, Riniken, Weiach and Benken) are analysed using high‐resolution X‐ray fluorescence core scanning. Data are compared to petrographic and additional geochemical data sets (inductively coupled plasma mass spectrometry, scanning electron microscopy with energy dispersive X‐ray analysis, micro‐X‐ray fluorescence mapping) obtained from powdered samples, thin section analyses and drill core slabs. The results demonstrate that the combination of these rapid and non‐destructive measurements along with multivariate data analysis allows the fast and objective classification of lithofacies along complex sedimentary successions. Moreover, it provides quantitative means for differentiating between prominent depositional and post‐depositional processes. The lithostratigraphic transition has been traced by the use of specific elemental proxies as a discontinuity, and its genesis linked to sediment bypassing

BIOINFORMATICS APPLICATIONS NOTE PIANA: Protein Interactions and Network Analysis

Summary: We present a software framework and tool called PIANA that facilitates working with protein interaction networks by 1) integrating data from multiple sources, 2) providing a library that handles graph-related tasks and 3) automating the analysis of proteinprotein interaction networks. PIANA can also be used as a standalone application to create protein interaction networks and perform tasks such as predicting protein interactions and helping to identify spots in a 2D electrophoresis gel. Availability: PIANA is under the GNU GPL. Source code, database and detailed documentation may be freely downloaded fro